MAPK8 and malignant colon neoplasm: Zhong et al. [50] found that the inflammatory factor IL-1β activated the transcription of miR-31 through p38 and JNK MAP kinase and its downstream transcription factors GATA2, c-Fos, and c-Jun, which negatively regulated the expression of E-selectin, thereby inhibiting the adhesion and migration of colon cancer cells to the endothelium and reducing the metastatic potential of colon cancer cells.