ANPEP and obesity due to melanocortin 4 receptor deficiency: In summary, APN treatment alleviated pathological changes in lung with reduction of eosinophils, total cell numbers in BALF, the eosinophil-attracting chemokine eotaxin and myeloperoxidase levels, which suggests that APN regulates cell migration into the airway and clearance of pulmonary inflammation in obesity-related asthma (30, 31).