CD8A and HIV-1 infection: Although the co-expression of IRs is a hallmark of CD8+ Tex in HIV-1 infection (Breton et al., 2013; Yamamoto et al., 2011; Cockerham et al., 2014; Rutishauser et al., 2017; Tauriainen et al., 2017; Chew et al., 2016; Trautmann et al., 2006), a detailed characterization of the combinatorial expression of IRs across CD8+ T-cell lineages in PLWH on long-term ART is still missing.