To investigate the link between misfolding and aggregation of tau protein and synapses alterations [12–14], we monitored the levels of two pre-synaptic proteins (Synaptophysin and Bassoon) and two post-synaptic scaffolding proteins (PSD95 and Homer) by western blots in cell lysates of cortical neurons inoculated with AD-tau cases. The gene discussed is DLG4; the disease is Alzheimer disease.