MAPT and Alzheimer disease: The mouse tau misfolding is dependent on the presence of misfolded human tau conformers, as control cultures in the medium do not show mouse tau aggregates (Fig. 3A), and even the neurons treated with AD-tau immunodepleted with combined Tau5/AT8 immunosorbent show no significant mouse tau aggregates compared to the original AD-tau inoculum applied (Fig. 4C).