These data are in agreement with the hypothesis of the diversity of misfolded tau species across individual AD cases and that the seeding-competent tau is likely to be a cloud of conformational entities such as oligomeric and soluble high-molecular weight forms, numerous transitional conformational states affected by post-translational modifications (PTMs), cofactors and physiochemical properties of aggregation environment [17, 18, 20, 28, 88, 89]. This evidence concerns the gene MAPT and Alzheimer disease.