Among the responders, we observed the activation of the PAX5 network in the immune regions adjacent (spatial gene expression clusters in direct contact) (Additional file 4: Fig. S3) to tumor clusters (Fig. 3A, Additional file 5: Fig. S4), while FOS and JUN modules are highly active in CAFs surrounding the tumor spots (Fig. 3B, C, Additional file 5: Fig. S4). The gene discussed is FOS; the disease is neoplasm.