Samples from patients that responded to CABO/NIVO are enriched for the expression of genes that belong to the pathways associated with active immune response (HALLMARK_INFLAMMATORY_RESPONSE, HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_ALLOGRAFT_REJECTION, HALLMARK_COMPLEMENT) and elevated antigen process and presentation machinery genes (Fig. 2D), suggesting that among responders, tumor intrinsic transcriptional features are leading to the increased immune cell infiltration observed in these samples relative to non-responders samples. This evidence concerns the gene NFKB1 and neoplasm.