Finally, the HSPB1 overexpression showed dynamic relief of the kinetics of cell death triggered by knockdown of circRNF10 in GSCs (Fig. 6o-q). In summary, downregulation of HSPB1 mediated by circRNF10 silencing is sufficient to remodel iron metabolism pool of the GSCs, rendering GBM susceptible to ferroptosis. Here, HSPB1 is linked to glioblastoma.