Interestingly, several ALS-FTD-related genes, including ubiquilin 2 (UBQLN2), valosin containing protein (VCP), optineurin (OPTN) and TANK binding kinase 1 (TBK1), are implicated in the autophagy-lysosome pathway [8, 25]. This evidence concerns the gene OPTN and frontotemporal dementia.