Notable examples include ALS/FTD-linked variants in genes like SQSTM1/p62, TBK1, C9orf72, OPTN, FIG4, ALS2, CHMP2B, FIG4 as well as FTD-causing mutations in TMEM106 or GRN [8, 26, 28, 29]. Here, OPTN is linked to amyotrophic lateral sclerosis.