The exosomes derived from A549-COX-2 cells upregulated the expressions of α-SMA, FN1, and FAP-1 in both MRC-5 and NIH-3T3 cells (Fig. 2D), suggesting that tumor-derived exosomes contribute to COX-2-mediated CAFs activation in LUAD. The gene discussed is PTPN13; the disease is neoplasm.