CUL3 and neoplasm: The findings of qRT-PCR assays showed that the exo-miR-1290 expression was increased greatly in A549-COX-2 injected tumors; Conversely, exo-miR-1290 expression was partially downregulated in A549-COX-2 + 3T3-CUL3 groups, which may attributed to the decreased tumor sizes in this group (Fig. 7A-E).