Studies showed that the severity of experimental autoimmune encephalomyelitis (EAE) increased after wild-type T cells were transplanted into LFA-1−/− recipient mice with encephalitis and that the Treg cell count in the spleen and thymus of these mice were lower than those in LFA-1+/+ mice, which indicated that the development of Treg cells was altered. Here, ITGAL is linked to encephalitis.