ITGAL and neoplasm: The results showed that compared to that in LFA-1+/+ +B16 mice (n = 7), the tumor volume in LFA-1−/− mice (n = 7) was significantly reduced (Fig. 1A**P < 0.01) and the tumor-to-body weight ratio was also reduced between the two groups (Fig. 1B, **P < 0.01).