In osteosarcoma (OS), lncRNA HCG18 competes for miR-365a-3p with PGK1, which is a key glycolytic coding mRNA, and moderates the repressive effect of miR-365a-3p on PGK1, thereby resulting in increased PGK1 expression and aerobic glycolysis and promoting the proliferation of OS cells [68]. The gene discussed is PGK1; the disease is osteosarcoma.