Medical subject headings (MeSH) terms included "ACTH independent macronodular adrenal hyperplasia," "Cushing's syndrome," "cryptococcal," and "Immune reconstitution inflammatory syndrome." Studies that analyzed cases of exogenous Cushing's syndrome without any treatment for Cushing's syndrome and patients with positivity for plasma human immunodeficiency virus (HIV) antibodies were all excluded. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.