During the spread of SARS-CoV-2, deficiency in type I interferon-dependent antiviral immunity caused by rare loss-of-function or hypomorphic TLR7 mutations emerged as a determinant of life-threatening COVID-19 in men under 60 [25–29], even though TLR7 engagement in pDCs may also promote the macrophage-induced cytokine storm in COVID-19 patients [23]. This evidence concerns the gene TLR7 and COVID-19.