RNF207 and familial dilated cardiomyopathy: As no variants in PRKAA2 passed our inclusion criteria in the UK Biobank cohort, we performed the analysis solely for RNF207. The seven RNF207 UK Biobank variants were present in 7 DCM cases and 874 controls, and the number of DCM cases and controls without these variants were 350 and 199,735, respectively.