Regarding PRAL tertiles, females with the highest PRAL had a higher odds of more severe depression compared to those in the lowest category in model 1 and model 3(OR = 1.15; 95% CI = 1.00–1.33 and OR = 1.17; 95% CI = 1.00–1.36, respectively). The gene discussed is PRAL; the disease is major depressive disorder.