These studies suggested that serotonin-5-HTR1E signaling regulates cell proliferation mainly through SRC-MEK-ERK pathway in ovarian cancer cells [19] Fig. 1B. Further, Gene sets enrichment analysis (GSEA) analysis in 5-HTR1E knock out SKOV-3 cells showed that 5-HTR1E inhibition upregulates genes of epithelial mesenchymal transition (EMT), extracellular matrix organization and metabolic pathways. The gene discussed is SRC; the disease is ovarian cancer.