Collectively, according to the results of this study, it might be concluded that the activation of inflammasome in the studied patients is defective for unknown reasons, and perhaps the uncontrolled inflammation in these patients is due to act of other inflammatory cytokines, which need to be investigated through assessment of the NLRP1, NLRP2, NLRP3, NLRC4, and AIM2 protein expression levels along with measurement serum levels of IL-6, IL-8, TNF-α in patients with COVID-19. The gene discussed is NLRP3; the disease is COVID-19.