KEGG pathway enrichment revealed that these genes were mainly enriched in the PI3K-Akt signaling pathway, protein processing in endoplasmic reticulum, complement and coagulation cascades, Alzheimer’s disease and proteoglycans in cancer (Fig. 12B), and the top two pathways were shown in Fig. S1. This evidence concerns the gene AKT1 and early-onset autosomal dominant Alzheimer disease.