MAPT and Alzheimer disease: The four main biomarkers found in cerebrospinal fluid (CSF), i.e., amyloid beta (Aβ)1–42, Aβ42/40 ratio, Tau, and phosphorylated-Tau (p-Tau)181, are reliable for supporting AD diagnosis as they indicate the hallmark AD pathologies of amyloidosis and neurodegeneration [3].