To identify glycolysis-dependent lymphoma-enabling mechanisms in an unbiased manner, we incubated acute oncogene-expressing ITK–SYK+PD-1− T cells and their premalignant ITK–SYK+PD-1+ counterparts with uniformly labeled [U-13C]glucose ex vivo and performed LC–MS/MS analysis to trace [U-13C]glucose-derived metabolites24. The gene discussed is SYK; the disease is lymphoma.