We detected a significant enrichment of c-FOS, FOSL1, FOSL2, c-JUN, and BATF target genes in H3K27ac ChIP–seq peaks upregulated in ITK–SYK+PD-1− lymphoma cells compared to their premalignant ITK–SYK+PD-1+ counterparts (Fig. 5c). This evidence concerns the gene FOS and lymphoma.