To dissect T cell lymphoma pathogenesis, we previously engineered a genetically controllable murine model of human T-NHL based on tamoxifen-inducible irreversible expression of the T-NHL oncogene ITK-SYK, which enforces strong oncogenic TCR signaling11, together with an enhanced green fluorescent protein (eGFP) reporter in individual mature CD4+ T cells in vivo (ITK-SYKCD4-CreERT2 mice; for the experimental system, see Fig. 1a,b)11,12. Here, ITK is linked to T-cell non-Hodgkin lymphoma.