Critically, late administration of IDX and MRT did not impact the viral load measured in the lungs of SARS-CoV-2-infected mice, while concurrently dampening critical inflammatory factors associated with severe COVID-19 in patients (e.g. IL-6 and IFN-γ) and decreasing airway neutrophil infiltration, which are correlated with disease severity28–32. Here, IFNG is linked to COVID-19.