TBK1 and infection: To define whether therapeutic targeting of TBK1 was superior to that of STING in the pathogenesis of severe SARS-CoV-2 infection, we next repeated a head-to-head comparison of the protective effect of IDX, MRT, and H151 in K18-hACE2 mice (noting that this experiment was terminated on day 5 post-infection due to several mice reaching the ethical endpoint across the different cohorts).