Conversely, IDX treatment prevented a decrease in Ifnar2 and Ifngr1 expression, which are both essential for type-I and type-II IFN signalling, but did not significantly alter the expression of other antiviral genes (e.g., Ifnb1, Oas1b, Oas2, or Mx2) at 6 days post-infection (Fig. 3h and Supplementary Fig. 3c), noting the dynamic expression of these genes in this model26. This evidence concerns the gene IFNB1 and infection.