Importantly, a long-term co-culture assay revealed that the expression of M1-like markers remained elevated, whereas M2-like markers remained lower in ACOD1-/- iMACs in three days (Fig. 4b), indicating that ACOD1 deletion could contribute to a long-term maintenance of higher pro-inflammatory activation and resistance to conversion toward the anti-inflammatory state in the presence of Nalm6 tumor cells. Here, ACOD1 is linked to neoplasm.