Using a highly permissive Vero E6-derived cell line Vero TA6 (Vero E6 overexpressing human TMPRSS2 and ACE2), we found that an authentic SARS-CoV-2 variant (USA-WA1/2020) mainly accumulated in a LAMP1 positive lysosomal compartment after infection (Fig. 1d, e), consistent with endocytosis being the major entry path for this variant13,24. The gene discussed is TMPRSS2; the disease is infection.