AGO2 and arbovirus infection: Our results showed that the mRNA abundance of these histone genes was significantly decreased in the midguts and carcasses of Ago2−/− females, with or without MAYV infection (Fig. 5i and Supplementary Fig. 7f), and with or without DENV2 infection (Supplementary Fig. 7g), when compared to the corresponding WT mosquitoes, indicating that Ago2 disruption affects the expression of histones, independent of arbovirus infection.