TIGIT and neoplasm: These studies also demonstrated that Fn could increase the accumulation of IFN-γ+CD8+ tumor-infiltrating lymphocytes, whereas a previous study noted that a decrease in the fold change in IFN-γ+CD8 T-cell anti-HIV Gag responses after anti-TIGIT and anti-PD-L1 blockade is correlated with higher Fusobacteria abundance20.