SNCA and Parkinson disease: In PD-vulnerable dopamine neurons from 95 brains (with available neuropathology stages), 26 circRNAs (including DNAJC6) showed suggestive associations with progressive alpha-synuclein-positive Lewy body burden—spanning brainstem-predominant, midbrain, and cortical stages of PD (e.g., based on the Unified Lewy Body Staging System50 of 0, I, IIa, III, and IV, see Supplementary Data 1).