The enriched KEGG pathways mainly included Pertussis, IL-17 signaling pathway, Influenza A, Coronavirus disease - COVID-19, Lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, Toll-like receptor signaling pathway, Cytokine-cytokine receptor interaction and MAPK signaling pathway (Fig. 3B). The gene discussed is RENBP; the disease is pertussis.