SIRT2 and cancer: SIRT2 is an NAD+-dependent deacetylase that is widely involved in cell division, angiogenesis [49–51], energy metabolism [52] and neurodegenerative [53,54], cardiovascular disease [55,56], oxidative stress [57] and many cancers [58,59], etc. Studies have found that SIRT2 was the most abundant sirtuin expressed in mammalian CNS, especially in cortex, striatum, hippocampus, and spinal cord, suggesting that it might have a role in CNS [60].