ERN1 and cancer: For example, ATF6-related pro-survival signaling was reported in gastric tumors (Jeong et al. 2015) and mutant p53 cancer cells (Sicari et al. 2019), whereas both XBP1s and IRE1 allow for the cells to tolerate high levels of MYC proto-oncogene and to avoid cell death (Tameire et al. 2015; Sheng et al. 2019; Zhang et al. 2020; Shajahan-Haq et al. 2014).