Additionally, some inflammatory and brain damage markers are well correlated with infarct growth and stroke outcomes (e.g., glial fibrillary acidic protein (GFAP), Amalia, 2021; D‐dimer, Zhang et al., 2021; brain derived neurotrophic factor (BDNF), Mojtabavi et al., 2022; and interleukin‐6 (IL‐6), Bustamante et al., 2014); therefore, members of these families could serve as ideal candidate biomarkers to reflect hypothermia biological responses. This evidence concerns the gene BDNF and stroke disorder.