KRAS and pancreatic intraductal papillary-mucinous neoplasm: Moreover, in 4 patients, we detected multiple KRAS mutations, either in the LG (patient IDs 6, 19, and 24) or in HG (patient ID 16), reiterating the prior observation of independent clonal events in IPMN pathogenesis (26), especially in LG lesions, with convergent evolution upon subsequent progression.