It is of importance to get a better understanding of whether vascular burden acts as a modifier of tau accumulation in both cognitively unimpaired and impaired individuals, since tau pathology is closely associated to cognitive decline and clinical progression across the entire AD continuum.27-29 This could improve our understanding of the pathophysiological mechanisms underlying AD dementia and thereby aid in the development of therapeutic strategies. The gene discussed is MAPT; the disease is Mental deterioration.