MAPT and Neurofibrillary tangles: Various kinases phosphorylate tau including cAMP‐dependent protein kinase, Cyclin‐dependent protein kinase 5 (Cdk5), stress‐activated protein kinases (SAPK), AMPK, GSK3, mitogen‐activated protein kinases, and Protein Kinase A. According to a great body of research, AMPK activation precedes tauopathy, suggesting its involvement in hyper‐phosphorylation of tau and subsequent formation of NFTs.76