After controlling for age, NIHSS, hypertension, diabetes, infarct volume, triglyceride, previous stroke, and toast classification, an elevated level of SERPINA3 was associated with a higher degree of CSO‐EPVS (OR, 3.06; 95% CI, 1.04–9.01; p = 0.042). Here, SERPINA3 is linked to hypertensive disorder.