SIGLEC1 and neoplasm: The sialic acid binding immunoglobulin-typelectin 1 (SIGLEC-1, Sn, CD169) is involved in uptake and presentationof dead cell-associated antigens, including tumor antigens.124 CD169 is expressed on a subpopulation of macrophageslocated in the marginal zone of the spleen and the lymphatic sinusesof secondary lymph nodes.