XCL1 fused toOVA or influenza antigens induces strong CD8+ T cell cytotoxicityin B6 mice.118,119 Fossum and colleagues performeda thorough comparative study of XCR1, Clec9a and DEC205 as potentialDC1 vaccine targets.118 Immunization withplasmid DNA encoding XCR1 or Clec9a targeted hemagglutinin (HA) protectedmice in a lethal viral challenge, whereas DEC205 targeted HA did not.Clec9a and DEC205 were targeted by nanobodies, whereas XCR1 was targetedvia XCL1. The gene discussed is CD8A; the disease is influenza.