AGT and hypertensive disorder: Disturbances in this ratio are found in many human bowel pathologies.98 In angiotensin II–dependent hypertension, the antibiotic minocycline rebalances the Firmicutes to Bacteroidetes ratio, reducing BP.99 Fecal matter transfer experiments show that the gut microbiome contributes to the salt-sensitive hypertension and renal injury in the Dahl salt–sensitive rat.100 CRISPR-Cas9 deletion of the Gper1 (G-protein–coupled estrogen receptor 1), protects against salt-sensitive hypertension in the Dahl rat.