ZEB1 and Familial prostate cancer: SIRT1 andDNMT3a are essential classes of modifiers in epigenetics.26,27 Nakane K. and coauthors showed that SIRT1 promotes EMT in PCa cells.Likewise, SIRT1 is enrolled via ZEB1 to bind the E-cadherin proximalpromoter; SIRT1 deacetylates the histone H3 and inhibits the RNA polymeraseII binding, resulting in the transcription blockage of E-cadherin.Thus, SIRT1 acts as a positive regulator of EMT to influence the metastaticgrowth of prostate cancer cells.28 Accordingly,the investigation functional role of DNMTs in PCa progression revealsDNMT3a to be upregulated in high Gleason score tumors.27