SIRT1 andDNMT3a are essential classes of modifiers in epigenetics.26,27 Nakane K. and coauthors showed that SIRT1 promotes EMT in PCa cells.Likewise, SIRT1 is enrolled via ZEB1 to bind the E-cadherin proximalpromoter; SIRT1 deacetylates the histone H3 and inhibits the RNA polymeraseII binding, resulting in the transcription blockage of E-cadherin.Thus, SIRT1 acts as a positive regulator of EMT to influence the metastaticgrowth of prostate cancer cells.28 Accordingly,the investigation functional role of DNMTs in PCa progression revealsDNMT3a to be upregulated in high Gleason score tumors.27 Here, ZEB1 is linked to posterior cortical atrophy.