Since, EMT has been implicated in carcinogenesisand confers metastaticproperties upon cancer cells by enhancing mobility, invasion, andresistance to apoptotic stimuli, TNFα-rich CM may be responsiblefor changes in epithelial–mesenchymal morphology; chronic exposuresto an inflammatory environment might be the major cause of a moreaggressive EMT hybrid phenotype. Here, TNF is linked to cancer.