NKX3-1 and metastatic prostate carcinoma: Previously,it has been shown that the inflammatory microenvironment suppressesNKX3.1 expression and causes LNCaP cell migration.19 However, although the loss of NKX3.1 provokes carcinogenesisin primary tumors, the cells maintain NKX3.1 expression even at alow level in metastatic prostate cancer.