3.3. Effects of Two GPCR Compounds Fulvestrant and Dexmedetomidine Hydrochloride on MafA and/or PDX-1 Expression in Pancreatic Islets Isolated in Type 2 Diabetic Mice where MafA and PDX-1 Expression Levels Are Substantially Reduced due to Glucose Toxicity. The gene discussed is PDX1; the disease is type 2 diabetes mellitus.