TARDBP and amyotrophic lateral sclerosis: Mammalian HSPB1, an ATP dependent chaperone in association with other chaperones of HSP-70 family, BAG2, BAG3 and HSP40, help in disassembly of de-mixed droplets of TDP-43 in ALS upon removal of stress thereby preventing the formation of TDP-43 gel like condensates (Lu et al., 2022).