TARDBP and amyotrophic lateral sclerosis: Neuronal RNP transport granules containing mutant TDP-43 display impaired transport in dendrites (Liu-Yesucevitz et al., 2014) and along the axon of primary cortical neurons or ALS patient iPSC-derived neurons (Alami et al., 2014; Gopal et al., 2017) as well as increased viscosity and loss of liquid-like properties (Gopal et al., 2017; Vishal et al., 2022).