However, in the hippocampus of FTD patients with TDP-43 pathology, SG RBPs show more inconsistent overlap with aggregates (Bentmann et al., 2012; Aulas and Vande Velde, 2015), and mature neurofibrillary tangles in AD patient tissue do not colocalize with SG markers (Maziuk et al., 2018). This evidence concerns the gene TARDBP and Alzheimer disease.