However, in the hippocampus of FTD patients with TDP-43 pathology, SG RBPs show more inconsistent overlap with aggregates (Bentmann et al., 2012; Aulas and Vande Velde, 2015), and mature neurofibrillary tangles in AD patient tissue do not colocalize with SG markers (Maziuk et al., 2018). Here, TARDBP is linked to frontotemporal dementia.