While a large body of evidence suggests ALS/FTD-linked mutations and associated aberrant RNP condensates have detrimental functional consequences for mRNA stability, transport, and translation in neurons, it is not clear that pathologic aggregation of TDP-43 and other RBPs in ALS/FTD necessarily requires aberrant condensate formation. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.