Indeed, a subset of TDP-43 positive aggregates and phosphorylated-tau in ALS/FTD and AD patient brain tissue, respectively, contain SG markers (Liu-Yesucevitz et al., 2010; Bentmann et al., 2012; Maziuk et al., 2018; Wolozin and Ivanov, 2019). This evidence concerns the gene TARDBP and frontotemporal dementia.