TARDBP and amyotrophic lateral sclerosis: Pathologic TDP-43 aggregates found in the majority of sporadic ALS cases display numerous post-translational modifications of wild type TDP-43, including phosphorylation, ubiquitination, cysteine oxidation, acetylation, and truncation (Neumann et al., 2006; Buratti, 2015; Cohen et al., 2015; Arseni et al., 2022).