The result was the appearance of PD-associated symptoms, such as cognitive impairments and motor deficiencies in mice, as well as the appearance of Lewy bodies, all of which appeared to be accompanied with changes in autophagy as well as receptors p62 and NBR1, confirming the involvement of macroautophagy in PD pathology (Ejlerskov et al., 2015). This evidence concerns the gene SQSTM1 and Parkinson disease.