Moreover, in the aging brain lamin B1 decline has not only been associated with loss of hippocampal neurogenic capability (Bedrosian et al., 2021) and astrocytic nuclear anomalies (Matias et al., 2022) but also with neurodegenerative diseases such as AD (Frost et al., 2016) and PD (Chinta et al., 2018). This evidence concerns the gene LMNB1 and neurodegenerative disease.