SUN1 and Hutchinson-Gilford progeria syndrome: In another study, declining lamin B1 with age was also observed, in vitro and in vivo, in mouse hippocampal NSC, whereas protein levels of SUN-domain containing protein 1 (SUN1) that has been previously implicated with Hutchinson-Gilford progeria syndrome, increased (around 4–6 months of age in rodents) (Bin Imtiaz et al., 2021).