MAPT and Alzheimer disease: In neurons of AD patients, pathological tau leads to the stabilization of actin filaments, disrupting the linkers of the nucleoskeleton to the cytoskeleton complex and reducing lamin B. Consequently, this results in relaxation of constitutive heterochromatin and activation of cell-cycle in post-mitotic neurons leading to neuronal death (Frost et al., 2016; Evangelisti et al., 2022).