The cells used for the experiments were MO3.13 (human oligodendrocytic cell line) and U87-MG (human glioblastoma astrocytic cell line) overexpressing LMNB1. The astrocytes were characterized by reduced secretion of leukemia inhibitory factor (LIF) that led to downregulation of pro-survival Janus kinase-signal transducer and activator of transcription protein 3 (Jak/Stat3) and phosphatidylinositol-3 phosphate kinase (PI3K)/Akt signaling pathways. The gene discussed is LIF; the disease is glioblastoma.