Altered theta-gamma coupling strength has commonly been used as a predictor of Alzheimer's disease and has been reported in both APP mice as well as hyperphosphorylated tau mouse models (Booth et al., 2016a,b; Ahnaou et al., 2017; Mably et al., 2017; Mably and Colgin, 2018; Etter et al., 2019; Jun et al., 2020; van den Berg et al., 2023). The gene discussed is MAPT; the disease is Alzheimer disease.