Drosophila and rat models of traumatic brain injury (TBI) exhibit abnormalities of multiple Nups, including Nup62, as well as RanGAP (Anderson et al., 2021), and both TBI-induced NCT deficits and lethality in Drosophila can be rescued by treatment with nuclear export inhibitor KPT-350 (Anderson et al., 2021). The gene discussed is RANGAP1; the disease is brain injury.