This study demonstrated that the cell-permeable peptides used decreased DPR production in BAC transgenic mice expressing (G4C2)500, in addition to decreasing DPR production and rescuing toxicity in a C9orf72-ALS patient-derived neuronal cell model and (G4C2)36-expressing Drosophila (Castelli et al., 2023). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.