ASO-mediated depletion of CHMP7 specifically rescued localization of POM121, Nup133, and Nup50, without disturbing localization of other Nups, and rescued the vulnerability of sALS and C9orf72-ALS iPSC-derived motor neurons to glutamate excitotoxicity (Coyne et al., 2021). This evidence concerns the gene POM121 and amyotrophic lateral sclerosis.