RAN and amyotrophic lateral sclerosis: Intriguingly, rare point mutations in LSM12 have been identified in ALS cohorts (http://databrowser.projectmine.com/), and expression of one of the variants, LSM12V135I, in SH-SY5Y cells and iPSC-derived neurons led to impaired NCT and disrupted Ran-GTPase gradient (Lee et al., 2020b).