However, the importance of co-aggregation of DPRs with Ran-GTPase cycle members in postmortem tissue is unclear, as double labeling for both GR and RanGAP failed to uncover differences in RanGAP localization in the presence or absence of GR inclusions in cortical motor neurons in C9orf72-ALS cases (Saberi et al., 2018). This evidence concerns the gene RAN and amyotrophic lateral sclerosis.