GLE1 and amyotrophic lateral sclerosis: GLE1 is proposed to play roles in stress granule dynamics (Aditi et al., 2015; Aditi Glass et al., 2016), and ALS-causing mutations reduced GLE1 localization at the NPC, leading to the proposal that toxicity occurs due to GLE1 haploinsufficiency (Kaneb et al., 2015).