PFN1 and amyotrophic lateral sclerosis: These effects were recapitulated using an actin-depolymerizing agent, Latrunculin A. Notably, FG-Nup mislocalization in primary neurons from PFN1 transgenic mice, as well as C9orf72-ALS patient fibroblasts, was reversed using an actin polymerization agent, IMM01, suggesting that modulating actin polymerization could modify NCT (Giampetruzzi et al., 2019).