Of all patients, 29 were subjected to a hormonal status evaluation and 26 were diagnosed with premature ovarian insufficiency (POI) (oligo/amenorrhoea for at least 4 months and FSH in the menopausal range levels >40 IU/L on two occasions > 6 weeks apart) (p < 0.001). Here, BRD2 is linked to Premature ovarian insufficiency.