Liver steatosis, transaminase levels, sex hormone disorders, and glucolipid metabolism were all found to be more severe in PCOS patients with obesity, as evidenced by the significant elevation in CAP, ALT, AST, TG, TC, LDL-C, TT, FAI, FIns, and HOMA-IR, and the significant decrease in HDL-C and SHBG levels in PCOS patients with obesity. The gene discussed is SHBG; the disease is polycystic ovary syndrome.