NADPH oxidase 2 (NOX2) was shown to be a major mediator of the inflammatory and adipocyte-clearing properties of MMe macrophages, and Nox2−/− mice exhibited insulin resistance, liver inflammation, and visceral lipoatrophy, characterized by deposition of dead adipocytes and dysfunctional ATM lysosomal exocytosis (51). Here, CYBB is linked to Insulin resistance.