MRC1 and obesity due to melanocortin 4 receptor deficiency: In agreement with findings described above (46), a recent study from our laboratory found a positive correlation between the level of insulin resistance in 80 patients with obesity and the pro-inflammatory ATM ratio between M1-like (CD206/CD11c expressing cells) and M2-like (CD206 expressing cells) in both VAT and subcutaneous AT (SAT) (29).