We found that early research concentrated on “#8 adiponectin” and “#9 morbid obesity”, interim studies concentrated on “#0 LPS”, “#2 oxidized fatty acids”, and “#6 fatty liver”, whereas current studies concentrated on “#1 metabolic syndrome (MS),” “#3 genetics”, and “#5 microbiome”, indicating changes in research hotspots. This evidence concerns the gene ADIPOQ and metabolic syndrome.