In particular, the risk allele (T) of the rs10811661 SNP correlates with reduced insulin secretory capacity (83, 84), higher HbA1c (p=2.15-10), prevalence of T2D and higher transcription of CDKN2A transcript in the human pancreas (while the other SNPs are not). This evidence concerns the gene CDKN2A and type 2 diabetes mellitus.