F10 and Venous thrombosis: They also express phosphatidylserine, which provides procoagulant surface for prothrombinase complexes to activate coagulation cascade, and exert pro-inflammatory effects by inducing neutrophil extracellular trap formation, enhancing leukocyte recruitment, and secreting granular contents to activate coagulation system, which further promote the development of venous thrombosis (26, 27).