Significant downregulation of the ileal epithelial AGTR1 and ADAM expression (both p = 0.0359) was seen in dogs with CIE compared to healthy controls (Figure 1B), which was also not mirrored in the colon (p = 0.7078 and p = 0.3487). This evidence concerns the gene AGTR1 and congenital non-bullous ichthyosiform erythroderma.