Significant upregulation of the ileal epithelial mRNA expression of the electrolyte transporters ATP1A1 (p = 0.0218), NHE3 (p = 0.0491), CLC-2 (p = 0.0009), and DRA (p = 0.0128), along with the glucose transporter SGLT1 (p = 0.0015), was detected in dogs with CIE compared to healthy controls (Figure 1A). This evidence concerns the gene SLC5A1 and congenital non-bullous ichthyosiform erythroderma.