Notably, SGLT1 mRNA expression was highly correlated with several RAAS components (Ang I, Ang III, Ang IV, aldosterone, PRA-S, and AA2 ratio) and the severity of diarrhea in dogs with CIE (Figure 3B). The gene discussed is SLC5A1; the disease is congenital non-bullous ichthyosiform erythroderma.