As an individual’s mood, anxiety, personality, and stress levels can all intersect to influence how the brain and gut interact with each other, our study’s purpose was to examine the impact of supplementing with a multi-strain probiotic on changes in mood, depression, personality, and anxiety as well as circulating concentrations of cortisol, C-reactive protein, serotonin, and dopamine. The gene discussed is CRP; the disease is depressive symptom measurement.